On my 45e, from NH to MI and back, with little opportunity to recharge, I averaged about 28mpg (that's over 2000-miles).
One's definition of a road trip is open ended, so without more details, the answers can be skewed considerably.
You'll see a big difference between cruising at 70 versus 80...the drag goes up with the square of the speed. That trip was mostly at about 75-mph on adaptive cruise. The 50e should get a little better unless you trounce on it.
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