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If you don't actually drive it to zero pressure (say it's a slow leak and you keep filling it up), functionally, it's no different than a 'normal' tire. The problem is, there's no way to tell if you actually have driven it with zero pressure, and any internal damage MIGHT not show, so the tire could be dangerous. Most shops don't want the liability.
Some of the Michelin (and maybe others) are ROF, rather than RFT. A subtle difference. A RFT tire is supposed to be be able to handle full load for 50-miles (as long as you don't exceed the speed limit). A ROF tire's ability to run flat will depend on the load, and only a lightly loaded vehicle can go 50-miles. A ROF tire tends to ride better as the sidewalls don't need to be quite as robust.
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