You can put runflats or non-runflats on any size rim. Remember since your car came with runflats you likely do not have a spare unless it was included on your build. As far as ride and comfort that is up to the different tires, you likely will notice a difference from 19" to 21" due to loss of sidewall and switching to a high performance tire. Be cautious switching to 21"s as you are VERY limited in tire choices and there is only one readily available all-season alternative.
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No. Try not. Do. Or do not. There is no try.
-Yoda
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